Calbru D,
60 tablets
DESCRIPTION:
The vast majority of calcium supplements that are commercially available are composed only of Calcium and Vitamin D3. Unfortunately, these dietary supplements do not provide all the necessary elements to combat calcium deficiencies as effectively as possible. After studying numerous scientific articles (see references below), our pharmaceutical team has identified certain ingredients whose effects are also beneficial and necessary and has integrated them into Calbru D, which allows Belgiophar to offer a much more complete supplement that is clearly preferable to the products currently available on the market. Calbru D not only provides the necessary calcium and vitamin D, but much more.
COMPOSITION:
USE:
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2 tablets daily with a meal.
PRACTICAL INFORMATION:
On osteoporosis:
Osteoporosis is a systemic bone disease that is common worldwide.
Osteoporosis, characterized by reduced bone mass, low bone mineral density (BMD) and deterioration of bone microstructure, increases the risk of mortality, including cardiovascular and cancer mortality.
The aetiology of reduced bone mass and osteoporosis development is related to multiple factors, including genetic, environmental, and dietary factors.
In addition, oxidative stress has been implicated as a causal factor in many disease, including decreased BMD. Consumption of natural antioxidant-rich foods and supplementation with isolated antioxidants can increase BMD and reduce the risk of fractures.
Therefore, an understanding of the role of dietary antioxidant nutrient intake in increasing BMD has important implications for improving preventive measures that can combat this important contributor to global morbidity and mortality.
(Guangze Xue and Rong Liu , Association between dietary selenium intake and bone mineral density in the US general population, Ann Transl Med. 2022 Aug; 10(16): 869. doi: 10.21037/atm-22-3441)
Folic Acid, Vitamin B12 and other B Vitamins:
Vitamin B12 and folic acid deficiency are associated with higher serum homocysteine concentrations. High serum homocysteine levels are a prevention factor for fractures.
(Karin M. A. Swart, Natasja M. van Schoor & Paul Lips : Vitamin B12, Folic Acid and bone , https://link.springer.com/article/10.1007/s11914-013-0155-2) New Evidence Supports Vitamin B's Role in Bone Health and Fracture Prevention (Elpida D. Sachinidi “Association of the B-complex vitamins with osteoporosis and osteoporotic fractures: Journal of Research and Practice on Musculoskeletal System).
Scientific articles on the benefits of supplementing with folic acid, vitamin B12, B vitamins and Nicotinamide:
https://link.springer.com/article/10.1186/s40199-014-0062-9
https://link.springer.com/article/10.1007/s11914-013-0155-2
https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.4070
https://www.frontiersin.org/articles/10.3389/fcell.2021.791880/full
https://www.jrpms.eu/articles/jrpms_v06i02_048.pdf
https://academic.oup.com/biomedgerontology/article/78/2/186/6678612?login=false
https://www.nature.com/articles/s41419-019-1569-2
https://www.spandidos-publications.com/mmr/22/1/145
Vitamin C and Vitamin E:
In their study "Effect of supplementation of vitamin C and E on oxidative stress in Osteoporosis", Sarita N. Chavan et al. write the following conclusion: The results indicate that the condition of the bones as a whole improved with prolonged supplementation with antioxidant vitamins, which can be used as a palliative treatment for osteoporosis. Efficacy is not affected if vitamins are administered alone or in combination. [...]
Scientific articles we recommend about vitamin C and Osteoporosis:
https://www.cambridge.org/core/journals/nutrition-research-reviews/article/is-there-a-role-for-vitamin-c-in-preventing-osteoporosis-and-fractures-a-review-of-the-potential-underlying-mechanisms-and-current-epidemiological-evidence/7CB3FBA7A80EEA34AFA8E0AE2F2A8DF6
https://link.springer.com/article/10.1007/BF02913324
Zinc:
While low zinc intakes and reduced blood levels of zinc have been associated with osteoporosis in women, the Rancho Bernardo study shows that zinc supplementation as well as plasma zinc levels have a positive association with bone density.
We recommend some scientific articles about zinc and osteoporosis:
https://link.springer.com/article/10.1007/s11010-009-0358-0
https://www.sciencedirect.com/science/article/pii/S0002916522035821
https://www.sid.ir/paper/272431/en
Magnesium
In 2009, EFSA's Panel concluded that a causal relationship had been established between dietary intake of magnesium (Mg) and the maintenance of normal bones.
Among other things, magnesium regulates the active transport of calcium. As a result, there is growing interest in the role of magnesium (Mg) in bone metabolism.
Scientific articles we recommend about magnesium and osteoporosis:
https://www.mdpi.com/2072-6643/5/8/3022
https://www.frontiersin.org/articles/10.3389/fmed.2020.00381/full
https://www.frontiersin.org/articles/10.3389/fnut.2021.738000/full
https://link.springer.com/article/10.1007/s10534-021-00305-0
https://academic.oup.com/nutritionreviews/article-abstract/53/3/71/1815191?login=false
Manganese:
Considering human studies that evaluated the efficacy of an oral manganese supplement for a long period of time (2 years) on bone mineral density in postmenopausal women (a total of 196 women), the two double-blind clinical trials that evaluated this topic showed that the loss of bone density was significantly greater in the placebo group than in the group taking manganese supplementation.
Manganese fights demineralization and osteoporosis. Its action protects cells through antioxidant power and helps in the formation of connective tissue.
We recommend a scientific article on Manganese and Osteoporosis:
https://journals.sagepub.com/doi/full/10.1177/1934578X211016649
Selenium:
In their study published on September 12, 2022, Patricia Paula da Fonsesca Grili et al. showed that Selenium consumption was associated with Bone Mass Density and that postmenopausal women with higher selenium intake were less likely to suffer from osteoporosis.
Scientific articles we recommend about selenium and osteoporosis:
https://www.frontiersin.org/articles/10.3389/fnut.2022.997414/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469114/
https://www.medicalnewstoday.com/articles/327122
https://www.sciencedirect.com/science/article/abs/pii/S8756328220304117
Collagen:
A thesis from 2010 demonstrated the beneficial effects of hydrolyzed collagen on bone health. Fanny Guillerminet's work has revealed that peptides derived from the intake of hydrolyzed collagen modulate bone metabolism by activating osteoblasts and inhibiting osteoclastic activity. By promoting bone formation, ingested hydrolyzed collagen has been shown to inhibit bone loss, strengthen the strength of growing bones, and improve the elasticity of mature bones. In addition, taking hydrolyzed collagen seems to have a preventive effect on bone loss. These properties make hydrolyzed collagen a potentially interesting dietary supplement.
Scientific articles we recommend about Collagen and Osteoporosis:
https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01060723/fullhttps://pastel.hal.science/pastel-00621193/document
https://www.medicalnewstoday.com/articles/collagen-for-osteoporosis
https://www.sciencedirect.com/science/article/pii/S2405844023021680
https://www.uclahealth.org/news/collagen-peptides-may-be-beneficial-menopausal-bone-
PRECAUTIONS FOR USE:
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Food supplements should be used as part of a healthy lifestyle and not used as a substitute for a varied and balanced diet.
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Do not exceed the recommended daily dose.
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Keep out of the reach and sight of young children.
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Store in a cool, dry place away from light, out of the fridge.
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The effects induced by taking this supplement may vary from one person to another.
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This product is not intended to diagnose, treat, cure or prevent any disease.
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This information does not constitute medical advice and should not be relied upon as such.
